Causes of Herpes
Genital herpes is a sexually transmitted infection caused by herpes simplex virus. This virus affects the genitals, the cervix, as well as the skin in other parts of the body.
People get infected mainly through secretion or touch elbows with the infected ones. Herpes type 1 usually infects the mouth, causing oral herpes, Herpes type 2 mostly invades the position below waist and brings about genital herpes, which is propagated mainly through sexual activity.
Following an infection by the Herpes simplex virus some people will experience an outbreak of genital herpes. The virus then becomes dormant (inactive) and remains in the body where you were infected. In some people the virus can become active again from time to time and cause further outbreaks of genital herpes
When pregnant women are infected by Herpes, the embryos will be infected too; new-born infants could be infected by secretion of genital tract during birth; infected infants younger than 7 weeks will suffer from extensive visceralization and central nervous system infections, and the mortality for them is usually high. Women of reproductive age or pregnancy should do serological examine of Herpes virus to protect fetus and infants from infection.
Symptoms of first outbreak of genital herpes
Feeling generally unwell with flu-like symptoms such as fever, tiredness, headache, swollen glands, aches and pains in the lower back and down the legs or in the groin.
Stinging, tingling or itching in the genital.
Small, fluid-filled blisters anywhere in the genital and these burst within a day leaving small, red sores which can be very painful.
Pain when passing urine
Symptoms of recurrent outbreaks are usually milder than with the first outbreak and clear up more quickly (in about a week).There is often an early warning tingling sensation and you may get a flu-like illness before an outbreak. The blisters and sores are usually fewer, smaller, and less painful and heal more quickly.
IgG and IgM Test
When a person becomes infected,the immune system tries to fight off the infection with the production of antibodies.The body can make several kinds of antibodies to fight infections.
The two types antibodies that herpes blood tests look for are IgG and IgM.
Herpes IgM antibodies usually are detectable by herpes blood tests within 7-10 days after initial infection. IgM levels stay high for approximately two weeks. After that, they usually decline. Therefore IgM testing is primarily considered to be useful for detecting acute infection. However antibodiy levels also sometimes go up during an outbreak.
In contrast, herpes IgG antibodies do not show up until slightly later after initial infection. A positive herpes IgG test, if the test result is accurate, means that your body has been infected with the herpes simplex virus.
Blood Test Results & Timing of Infection
If you test positive for herpes IgG but not IgM, then your herpes infection is probably not recent. You've probably been infected for at least two months.
Individuals with newer infections are more likely to test positive for both herpes IgG and IgM. They might also be positive for herpes IgM alone.
Positive herpes IgG and IgM results together do not necessarily mean you were infected recently. Between 30 and 70 percent of patients with recurrent herpes infections will test positive for herpes IgM.
Test Results and Timing of Infection
Positive IgM / Positive IgG = Infection date indeterminate
Positive IgM / Negative IgG = Acute/Recent infection
Negative IgM / Positive IgG = Established Infection
Negative IgM / Negative IgG = No infection
1. Allow test device and sample to equilibrate to room temperature prior to testing.
2. Remove the test device from the foil pouch and lay it flat on a clean, dry and non-absorbent surface.
3. Dispense 2 drops (80-100ul) serum/blood specimen into each sample well and read results within 25-30 minutes.